Mechanistic Biomarkers in Toxicology

Biomarkers in neurodevelopmental toxicology.

Tailored gene array databases: applications in mechanistic toxicology

MOTIVATION The development of an annotated global database suitable for a wide range of investigations is a challenging and labor-intensive task. Thus, the development of databases tailored for specific applications remains necessary. For example, in the field of toxicology, no annotated gene array databases are now available that may assist in the correlation of changes in gene activity to cel...

A computational approach to mechanistic and predictive toxicology of pesticides.

Emerging challenges of managing and interpreting large amounts of complex biological data have given rise to the growing field of computational biology. We investigated the applicability of an integrated systems toxicology approach on five selected pesticides to get an overview of their modes of action in humans, to group them according to their modes of action, and to hypothesize on their pote...

Aflatoxin: a 50-year odyssey of mechanistic and translational toxicology.

Since their discovery 50 years ago, the aflatoxins have become recognized as ubiquitous contaminants of the human food supply throughout the economically developing world. The adverse toxicological consequences of these compounds in populations are quite varied because of a wide range of exposures leading to acute effects, including rapid death, and chronic outcomes such as hepatocellular carci...

Biomarkers in environmental toxicology: state of the art.

Together with many other research-based disciplines, environmental toxicology has profoundly benefited from recent advances in molecular biology and analytical chemistry. As a result of these accomplishments, clinical and experimental studies of biomarkers have developed into a multidisciplinary research area. The IFCC has convened two conferences: to review biomarkers of chemical exposure, in ...